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[Preprint]. 2023 Sep 17:2023.02.03.527061. Originally published 2023 Feb 4. [Version 3] doi: 10.1101/2023.02.03.527061

Figure 4. Many circadian genes are divergently regulated between modern humans and archaic hominins.

Figure 4.

Comparison of the imputed regulation of core circadian genes between 2504 humans in 1000 Genomes Phase 3 (gray bars) and three archaic individuals (vertical lines). For each core circadian gene, the tissue with the lowest average P-value for archaic difference from humans is plotted. Archaic gene regulation is at the extremes of the human distribution for several core genes: CRY1, PER2, NPAS2, NR1D1 RORA. See Figure S2 for all core clock genes and Figure S3 for all divergently regulated circadian genes.