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[Preprint]. 2023 Feb 2:rs.3.rs-2501039. [Version 1] doi: 10.21203/rs.3.rs-2501039/v1

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Figure 8: — a PNN-enclosed PV neurons receive glutamatergic inputs in the PNN holes wherein astrocytic processes are also confined (magnified area) and make this space analogous to the tripartite synapse.

b Under physiological conditions, when PNN is intact (top), glutamate released during synaptic activity and extracellular potassium ions released upon neuronal repolarization are directed towards astrocytic processes by the PNN to aid efficient clearance of extracellular glutamate and potassium. When PNNs are disrupted (bottom), glutamate and potassium ions escape from and diffused laterally into the extracellular space.