Table 4.

Summary of genes with 30 or more prioritized VUSs per 1000 amino acids in length. A comprehensive list of all prioritized VUSs is available in Table S4. These VUSs were prioritized based on having a ΔΔGFold > 1.8 and a CADD score >25.7.

Gene	Protein Family	Variant Density	Protein Length	# VUSs	Mean ΔΔGFold	Mean CADD
ATP6V1B1	ATPase	33.1	513	17	2.8	27.8
CDC14A	Tyrosine phosphatase	36.9	623	23	2.7	28.3
CLRN1	Clarin	43.1	232	10	2.3	26.6
DCAF17	Not assigned	42.3	520	22	3.2	27.9
DIABLO	Not assigned	58.6	239	14	2.7	28.4
ELMOD3	Not assigned	31.5	381	12	3.1	27.6
GIPC3	GIPC	41.7	312	13	3.1	27.5
GJB2	Connexin	44.2	226	10	3.1	27.6
GJB3	Connexin	40.7	270	11	3.4	27.3
GRXCR1	GRXCR1	34.5	290	10	2.8	27.6
GSDME	Gasdermin	38.3	496	19	3.4	27.4
HARS2	Aminoacyl-tRNA synthetase	33.2	512	17	2.7	28.8
KARS1	Aminoacyl-tRNA synthetase	30.4	625	19	2.7	28.3
LHFPL5	LHFP	32.0	219	7	3.3	28.4
LOXL3	Lysyl oxidase	35.9	753	27	3.0	27.8
MANBA	Glycosyl hydrolase	30.7	879	27	3.1	27.7
MASP1	Peptidase	50.8	728	37	3.1	28.6
MSRB3	Sulfoxide reductase	37.8	185	7	3.4	28.3
MYO3A	Myosin-kinesin ATPase	38.4	1616	62	3.0	28.4
MYO6	Myosin-kinesin ATPase	30.9	1294	40	3.1	27.9
MYO7A	Myosin-kinesin ATPase	39.3	2215	87	3.0	28.0
NARS2	Aminoacyl-tRNA synthetase	46.1	477	22	2.8	28.3
OTOF	Ferlin	30.0	1997	60	3.2	28.4
OTOGL	Otogelin	61.0	2344	143	3.1	28.2
PCDH15	Not assigned	30.7	1790	55	3.1	27.9
POLR1C	RNA polymerase	46.2	346	16	2.9	27.9
RDX	Not assigned	39.7	604	24	3.0	27.5
SEMA3E	Semaphorin	31.0	775	24	3.3	28.1
SLC17A8	Sodium/anion cotransporter	30.6	589	18	2.8	28.9
SLC19A2	Thiamine transporter	70.4	497	35	3.5	28.1
SLC22A4	Cation transporter	38.1	551	21	3.0	28.3
SLC26A4	SLC26A/SulP transporter	57.7	780	45	2.9	28.1
SLC44A4	Choline transporter-like	54.9	710	39	3.0	28.5
SLC52A2	Riboflavin transporter	36.0	445	16	3.2	26.9
SLC52A3	Riboflavin transporter	34.1	469	16	3.2	27.3
TECTA	Not assigned	39.0	2155	84	3.1	28.0
TMC1	TMC	31.6	760	24	3.3	29.0
TSPEAR	Not assigned	31.6	601	19	3.5	28.1
WFS1	Not assigned	51.7	890	46	3.0	27.7