Skip to main content
. 2023 Jan 18;24(3):1891. doi: 10.3390/ijms24031891

Figure 3.

Figure 3

Pathway in which differentially expressed miRNAs could be involved, potentially related to the antipsychotic resistance in schizophrenia. MiRNAs are colored according to their expression in the MNR group when compared to the MR group; red indicates overexpression and blue underexpression. Sirtuin 1 (SIRT1) interacts with the DNA Methyltransferase 1 (DNMT1) and the Tumor Protein P53 (p53) regulating its expression. Proteins MDM2 Proto-Oncogene (MDM2), MAGE Family Member C2 (MAGEC2), and RING Finger Protein 96 (TRIM28) are closely linked with p53 inactivation and heavily targeted by the miRNAs of our TRS profile. This inactivation of p53 is through ubiquitination (p53Ub), which leads to its degradation. Acetylated p53 (p53Ac) acts as a transcriptional factor of several genes, from which Tumor Protein P53 Inducible Nuclear Protein 1 (TP53INP1) is the one most targeted by the TRS profile. This protein is a positive regulator of the autophagy and also acts as a transcription regulator in response to cellular stress. This regulation is made through its interaction with GABA Type A Receptor-Associated Protein (GABARAP), with GABA Type A Receptor Associated Protein Like 1/2 (GABARAPL1, GABARAPL2) and with Microtubule Associated Protein 1 Light Chain 3 Alpha/Beta/Gamma (MAP1LC3A, MAP1LC3B, MAP1LC3B).