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. 2023 Feb 10;299(3):103004. doi: 10.1016/j.jbc.2023.103004

Figure 1.

Figure 1

SARS-CoV-2 Mproamino acids polymorphisms identified in the genomic database.A, Mpro model showing variant spots identified in the genomic database, using a threshold of n ≥ 10. The Cα of identified variants spots are shown as cyan spheres, while red spheres are those variants within a radius of 8 Å ligands. Orange spheres show spots for variants of concern. Active site of Mpro is colored with a green blob. B, 2D plot of nirmatrelvir showing the distance and closest contacts with selected polymorphisms. C, 2D plot of ensitrelvir showing the distance and closest contacts with selected polymorphisms. D, panel containing polymorphism name, and substitution, and number of individuals identified (n) in a pool of 7 million SARS-CoV-2 genomes cataloged at CoV-GLUE by December 2021.