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. 2023 Feb 10;299(3):103004. doi: 10.1016/j.jbc.2023.103004

Figure 2.

Figure 2

SARS-CoV-2 Mpropolymorphisms kinetics and inhibitions plots.A, Michaelis–Menten plots of WT and mutants M49T, M49I, N142S, N142D, G143S, M165I, R188S, and R188K. B, Michaelis–Menten plots of WT and mutants Q189K, T190I, A191T, A191V, A193V, A193S, and A193T. C, IC50 plots determination of nirmatrelvir against WT and mutants M49T, M49I, N142S, N142D, G143S, M165I, R188S, and R188K. D, IC50 plots determination of nirmatrelvir against WT and mutants Q189K, T190I, A191T, A191V, A193V, A193S, and A193T. E, IC50 plots determination of ensitrelvir against WT and mutants M49T, M49I, N142S, N142D, G143S, M165I, R188S, and R188K. F, IC50 plots determination of ensitrelvir against WT and mutants Q189K, T190I, A191T, and A191V. Data in graphs are means ± SD.