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Crystal structures of Mproin complex with ensitrelvir. Mpro is displayed as cartoon and colored in gray; mutant residue is shown as spheres and colored in blue. Selected residues are displayed as yellow sticks. Ensitrelvir is shown as ball and stick and colored in cyan. Substrate-binding subsites are labeled in red. A, Mpro WT (PDBid 8DZ0). B, mutant M49I (PDBid 8DZ1) aligned with Mpro WT, displayed as gray transparent sticks. Polar contacts are showed as black dashes.
