Figure 1.

An example of a domain sequence neighborhood (Trypsin-like domains). Each domain corresponds to one dot in the figure. NSD, number of similarities to the group (i.e. to trypsin domains); AVS, average of group similarities. The members of the group (‘self’) are shown as circles and domains that are not members but still have a significant (P < 1) similarity with the group (‘non-self’) are shown as triangles. (Inset) Schematic representation of the statistical parameters (•) and (•). Values of and are simply read out from the precomputed empirical distributions. A similar procedure is followed for the AVS scores. The resulting six values are combined to calculate a probabilistic score (4) or used as the input parameters of artificial neural networks (5).