Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
IC50 values for perampanel inhibition in voltage-clamp recordings from recombinant homomeric and heteromeric KARs expressed in HEK293-T/17 cells (adapted from ref. [166]).
| Receptor | IC50 [μM] |
|---|---|
| GluA4 | 0.56 ± 0.12 |
| GluK1 | 19 ± 5 |
| GluK2 | 26 ± 10 |
| GluK3 | 41 ± 6 |
| GluK1/5 | 2.8 ± 0.3 |
| GluK2/5 | 0.85 ± 0.09 |
| GluK3/5 | 14 ± 8 |
| GluK1/NETO1 | 11 ± 4 |
| GluK1/NETO2 | 19 ± 4 |
| GluK2/NETO1 | 5.4 ± 0.9 |
| GluK2/NETO2 | 5.8 ± 1.0 |
| GluK1/5/NETO2 | 0.99 ± 0.15 |
| GluK2/5/NETO1 | 0.69 ± 0.16 |
