Table 2.
Baseline (admission to the ICU) patient characteristics and day-28 (D28) mortality
| Variable | All patient (n = 2600) |
Dead on D28 (n = 966) | Alive on D28 (n = 1634) | OR [95% CI] |
p value |
|---|---|---|---|---|---|
| Age (years) | < 0.001 | ||||
| < 52 | 649 (25) | 175 (18.1) | 474 (29) | Ref | |
| [52–64] | 691 (26.6) | 256 (26.5) | 435 (26.6) | 1.59 [1.25; 2.04] | |
| [65–73] | 618 (23.8) | 223 (23.1) | 395 (24.2) | 1.53 [1.19; 1.97] | |
| ≥ 74 | 642 (24.7) | 312 (32.3) | 330 (20.2) | 2.46 [1.91; 3.16] | |
| SAPS II score on ICU admission (age excluded)a | < 0.001 | ||||
| < 26 | 585 (22.5) | 186 (19.3) | 399 (24.4) | Ref | |
| [26–35] | 708 (27.2) | 227 (23.5) | 481 (29.4) | 1.09 [0.84; 1.39] | |
| [36–47] | 618 (23.8) | 223 (23.1) | 395 (24.2) | 1.37 [1.06; 1.77] | |
| ≥ 48 | 689 (26.5) | 330 (34.2 | 359 (22) | 2.28 [1.78; 2.93] | |
| Male gender | 1657 (63.7) | 596 (61.7) | 1061 (64.9) | 0.89 [0.75; 1.06] | 0.192 |
| Body Mass Index (kg per m2) | |||||
| < 18.5 | 98 (3.8) | 32 (3.3) | 66 (4) | 1 | 0.771 |
| [18.5; 30] | 1845 (71.1) | 687 (71.3) | 1158 (71) | 1.13 [0.71; 1.78] | |
| ≥ 30 | 652 (25.1) | 245 (25.4) | 407 (25) | 1.18 [0.73; 1.9] | |
| Charlson comorbidity index | |||||
| 0 | 792 (30.5) | 223 (23.1) | 569 (34.8) | 1 | < 0.001 |
| 1–2 | 935 (36) | 371 (38.4) | 564 (34.5) | 1.59 [1.28; 1.97] | |
| > 2 | 873 (33.6) | 372 (38.5) | 501 (30.7) | 1.83 [1.47; 2.28] | |
| Solid tumor, no metastasis | 242 (9.3) | 88 (9.1) | 154 (9.4) | 0.99 [0.74; 1.32] | 0.931 |
| Solid tumor, with metastasis | 159 (6.1) | 76 (7.9) | 83 (5.1) | 1.54 [1.09; 2.17] | 0.013 |
| Haematological malignancy | 159 (6.1) | 71 (7.3) | 88 (5.4) | 1.55 [1.1; 2.2] | 0.013 |
| Type of ICU admission | |||||
| Medical | 1922 (73.9) | 777 (80.4) | 1145 (70.1) | 1 | < 0.001 |
| Surgical elective | 186 (7.2) | 56 (5.8) | 130 (8) | 0.69 [0.49; 0.97] | |
| Surgical emergency | 492 (18.9) | 133 (13.8) | 359 (22) | 0.6 [0.47; 0.76] | |
| Primary ICU admission diagnosisb | |||||
| Sepsis or septic shock | 530 (20.4) | 189 (19.6) | 341 (20.9) | 1 | < 0.001 |
| Respiratory admissionb | 550 (21.2) | 232 (24) | 318 (19.5) | 1.14 [0.88; 1.48] | |
| COVID-19b | 336 (12.9) | 195 (20.2) | 141 (8.6) | 2.07 [1.5; 2.85] | |
| Post-operative admission | 258 (9.9) | 83 (8.6) | 175 (10.7) | 0.84 [0.6; 1.17] | |
| Other admission diagnoses | 926 (35.6) | 267 (27.6) | 659 (40.3) | 0.68 [0.53; 0.87] | |
Continuous variables are presented as median [IQR]. Categorical variables are presented as n (%). CI: confidence interval. Closed brackets [;] denote inclusive of the end of the range and open brackets]; [denote the exclusion of the end of the range. ICU: Intensive care unit, SAPS II: Simplified Acute Physiology Score II
aThe SAPS II score was calculated excluding age-related points to avoid collinearity
bRespiratory admission refers to admission for respiratory failure other than COVID-19 that has been categorized separately. A full list of co-morbidities as defined in Charlson score and admission diagnosis can be found in the electronic supplement eTable 3