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Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
Schematic representation of a CYP4B1-based suicide gene system. CYP4B1-deficient cells are transduced with integrating viral vectors to express an active CYP4B1 protein. This enzyme converts a non-toxic substance (protoxin) into a cellular toxin only in CYP4B1-positive cells.