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. 2023 Jan 20;24(3):2038. doi: 10.3390/ijms24032038

Figure 3.

Figure 3

Schematic representation of a CYP4B1-based suicide gene system. CYP4B1-deficient cells are transduced with integrating viral vectors to express an active CYP4B1 protein. This enzyme converts a non-toxic substance (protoxin) into a cellular toxin only in CYP4B1-positive cells.