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. 2023 Jan 31;24(3):2667. doi: 10.3390/ijms24032667

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Ultrastructure of bAVICs from 15-day-long pro-calcific cultures. (A–C) Enlargement of RER cisternae (arrowheads) and RER membrane lysis, with ribosome release and merging with the nearby phthalocyanine-positive material (single asterisk: less condensed PPM; double asterisk: more condensed PPM) derived from ongoing membranous organelle degeneration. (D) Immunogold labelling of rRNA with gold particles (white arrowheads) decorating the intracellular PPM (asterisk) and a cross-sectioned degenerating RER cisterna (black arrowhead). (E) Cell-derived byproducts showing a mix of PPM (asterisk) and more electrondense phthalocyanine-positive layers (PPLs; counterposed arrowheads). (F₁,F₂) Immunogold labelling of rRNA showing gold particles within PPM (asterisks) and PPLs (counterposed arrowheads) at the level of vesicular cell debris. Bar: 0.5 μm (A–C,E); 0.25 μm (D,F₁,F₂).

Ultrastructure of bAVICs from 15-day-long pro-calcific cultures. (A–C) Enlargement of RER cisternae (arrowheads) and RER membrane lysis, with ribosome release and merging with the nearby phthalocyanine-positive material (single asterisk: less condensed PPM; double asterisk: more condensed PPM) derived from ongoing membranous organelle degeneration. (D) Immunogold labelling of rRNA with gold particles (white arrowheads) decorating the intracellular PPM (asterisk) and a cross-sectioned degenerating RER cisterna (black arrowhead). (E) Cell-derived byproducts showing a mix of PPM (asterisk) and more electrondense phthalocyanine-positive layers (PPLs; counterposed arrowheads). (F₁,F₂) Immunogold labelling of rRNA showing gold particles within PPM (asterisks) and PPLs (counterposed arrowheads) at the level of vesicular cell debris. Bar: 0.5 μm (A–C,E); 0.25 μm (D,F₁,F₂).