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Pathways of conversion of n-6 polyunsaturated fatty acids and their lipid mediator derivatives [1,4,5]. Note that not all enzymes are named, or derivatives shown. ARA = arachidonic acid, COX = cyclooxygenase, DGLA = dihomo-γ-linolenic acid, DS = desaturase, GLA = γ-linolenic acid, 15-HETrE = 15-(S)-hydroxy-8,11,13-eicosatrienoic acid, HODE = hydroxyoctadecadienoic acid, LA = linoleic acid, LOX = lipoxygenase, LT = leukotriene, LX = lipoxin, PG = prostaglandin, TX = thromboxane.
