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. 2023 Jan 19;24(3):1994. doi: 10.3390/ijms24031994

Figure 1.

Figure 1

Survival rate of zebrafish embryos at different developmental stages (hours post fertilization, hpf) after exposure to cabotegravir (CAB) by the immersion method. (A) CAB chemical structure. (B) Overall experimental design. (C) Dechorionated zebrafish embryos were exposed at gastrula stage (4 hpf) to drug solvent only (fish water plus 0.1% dimethyl sulfoxide, DMSO) [CO] or CAB, dissolved in fish water containing 0.1% DMSO. X-axis shows drug doses used for exposure of embryos; Y-axis shows the corresponding survival percentages at the different developmental stages (48 hpf, blue line; 72 hpf, red line; 96 hpf, green line; 120 hpf, violet line). Results are expressed as mean ± SD of three independent experiments, with 30 embryos for each experiment and each treatment. (** p < 0.005 vs. control group).