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. 2023 Jan 18;24(3):1919. doi: 10.3390/ijms24031919

Figure 2.

Figure 2

Schematic representation of the role of melatonin in the circadian system. In mammals, circadian rhythms are regulated by circadian clocks. The central clock is located in the SCN of the hypothalamus and controls pineal melatonin secretion in the absence of light, while melatonin also affects the SCN, which regulates chronobiotic activities. In peripheral tissues, clock genes are synchronized by the SCN and are also influenced by melatonin. Suprachiasmatic nucleus (SCN). Image created using BioRender.com (accessed on 22 November 2022).