Figure 1.

Contribution of the main cellular and soluble mediators studied in NAFLD development. α-SMA, α-smooth muscle actin; CTGF, connective tissue growth factor; FGF, fibroblast growth factor; GROα, growth regulated protein-α; hs-CRP, high-sensitivity C-reactive protein; HSCs, hepatic stellate cells; IFNγ, interferon-γ; IL, interleukin; MCP-1, monocyte chemoattractant protein-1; MPO, myeloperoxidase; NAFL, non-alcoholic fatty liver; NAFLD, non-alcoholic fatty liver disease; NASH, non-alcoholic steatohepatitis; NKT, natural killer T; PDGF, platelet-derived growth factor; SREBP1, sterol regulatory element binding protein-1; TGF-β, transforming growth factor-β; Th, T helper; TLR9, toll-like receptor 9; TNFα, tumor necrosis factor-α.