Table 1.
Correlations between NAFLD features and cellular or soluble markers.
| NAFLD Features | Correlation | Marker | References |
|---|---|---|---|
| Liver inflammation | + | MPV | [48] |
| + | Intrahepatic T-lymphocyte frequency and aggregates | [77] | |
| + | Circulating IL-18 levels | [142] | |
| + | Hepatic IL-6 expression | [150] | |
| NR | Peripheral percentage of IFNγ-producing T cells | [83] | |
| NR | Circulating MCP-1/CCL2 levels | [133] | |
| Steatosis | + | MPV | [48,49] |
| + | Circulating hs-CRP levels | [101,104,106] | |
| + | Hepatic IL-17A mRNA expression | [153] | |
| + | Hepatic MCP-1/CCL2 mRNA expression | [128,129,130] | |
| − | Peripheral activated (NKG2D+) NKT cell frequency | [20] | |
| NR | Peripheral percentage of IFNγ-producing T cells | [83] | |
| NR | Circulating MCP-1/CCL2 levels | [133] | |
| Fibrosis | + | MPV | [48] |
| + | Neutrophil/lymphocyte ratio (NLR) | [48,57,63,66,67] | |
| + | Intrahepatic T-lymphocyte frequency and aggregates | [77] | |
| + | Circulating IFNγ levels | [77] | |
| + | Circulating MCP-1/CCL2 levels | [133] | |
| + | Circulating IL-18 levels | [143] | |
| + | Circulating hs-CRP levels | [101,105] | |
| + | Hepatic IL-6 expression | [150] | |
| − | Hepatic NK cell frequency | [20] | |
| NR | Peripheral T-lymphocyte counts | [20] | |
| NR | Peripheral percentage of IFNγ-producing T cells | [83] | |
| Liver injury | + | MPV | [48] |
| + | TLR9 expression on circulating CD4+ or CD8+ cells | [78] | |
| + | Circulating MCP-1/CCL2 levels | [133] | |
| + | Circulating IL-18 levels | [142] | |
| NR | Peripheral percentage of IFNγ-producing T cells | [83] | |
| Body mass index | + | Hepatic MPO mRNA expression | [61] |
| + | TLR9 expression on circulating CD4+ or CD8+ cells | [78] | |
| Dysglycemia | + | Hepatic MPO mRNA expression | [61] |
| + | Hepatic IL-6 expression | [150] | |
| Hypertriglyceridemia | + | TLR9 expression on circulating CD8+ cells | [78] |
(+) positive correlation; (−) negative correlation; (NR) not related. Abbreviations: hs-CRP, high-sensitivity C-reactive protein; IFNγ, interferon-γ; MCP-1, monocyte chemoattractant protein-1; MPO, myeloperoxidase; MPV, mean platelet volume; TLR9, toll-like receptor 9.