Table 2.
IC50 values (μM) obtained for Pt complexes on HaCaT, A431, BALB/c-3T3 and SVT2 cells after 48 h incubation. The selectivity indexes (SI) are indicated by the ratios between the IC50 values of the immortalized cells and cancer cells.
| HaCaT | A431 | SI | BALB-c/3T3 | SVT2 | SI | |
|---|---|---|---|---|---|---|
| 1-Me,Me | 8.4 ± 1.7 | 20 ± 2 | 0.42 | 26 ± 1 | 9.8 ± 0.3 | 2.65 |
| 1-Me,Oct | 8.0 ± 0.1 | 7.3 ± 0.4 | 1.1 | 8.3 ± 0.4 | 7.6 ± 1.1 | 1.09 |
| 1-Oct,Me | 6.4 ± 1.0 | 2.3 ± 0.1 | 2.78 | 7.1 ± 0.1 | 8.6 ± 0.6 | 0.83 |
| 1-Oct,Oct | 6.4 ± 0.8 | 5.0 ± 0.6 | 1.28 | 7.3 ± 0.7 | 4.5 ± 1.3 | 1.62 |