Table 2.
The results of in vitro cytotoxicity against selected human cancer cell lines (A2780, A2780R, PC-3, 22Rv, THP-1, and LS180) and healthy (MRC5) cells. IC50 values are given in µM together with the standard deviations, and they are based on triplicate experiments. The abbreviation n.d. means that the value has not been determined.
| Compound | Human Cell Lines | ||||||
|---|---|---|---|---|---|---|---|
| A2780 | A2780R | PC-3 | 22Rv1 | THP-1 | LS180 | MRC5 | |
| [Au(kin)(PPh3)] (1) | 2.9 ± 0.7 | 5.0 ± 1.5 | 4.8 ± 1.3 | 3.7 ± 0.5 | 1.1 ± 0.2 | >10 | >10 |
| Kinetin | >25 | >25 | >25 | n.d. | n.d. | n.d. | >25 |
| [Au(PPh3)Cl] | 3.5 ± 0.5 | 5.2 ± 0.2 | 9.9 ± 0.4 | n.d. | n.d. | n.d. | 17.0 ± 0.5 |
| Auranofin | 3.4 ± 0.9 | 3.4 ± 0.6 | 3.7 ± 0.7 | n.d. | n.d. | n.d. | 3.78 ± 0.01 |
| Cisplatin | 17.2 ± 0.9 | >50 | >50 | 28.2 ± 4.2 | n.d. | >50 | >50 |