Table 1.

Inflammatory and regulatory B cell subsets in MS/EAE.

Inflammatory B Cells	Source	Functions
Memory B cells	MS patients	Antigen presentation
		Pro-inflammatory cytokine production
	EAE mice	Exacerbates EAE
		Produces IL-6
IgG + plasma cells	CNS Lesions in MS patients	Oligoclonal bands
		Auto-antibody production
	EAE mice	Facilitate CNS damage
		Increases disease severity
Regulatory B Cells
Naïve B cells	MS patients	High levels of IL-10
Bregs/Transitional B cells	MS patients	Produce IL-10, IL-35, TGF-β
		Suppresses TNF production by monocytes.
	EAE mice	Produce IL-10
		Inhibits TH1 and TH17 cells
IgA + plasma cells	EAE mice	Attenuates EAE
		Produces IL-10