Table 2.

Effects of MS therapies on B cells.

MS Therapies	Mechanism of Action
Anti-CD20	Removes all B cell subsets except pro-B cells and plasma cells
	Depletes IL-6 producing B cells
Interferon	Elevates serum BAFF levels
	Increases IL-10 producing transitional B cells
	Decreases memory B cells
Dimethyl fumarate	Reduces memory B cells
	Spares transitional B cells
	Decreases pro-inflammatory cytokines GM-CSF, IL-6 and TNF-α
Fingolimod	Blocks egression of inflammatory cells from secondary lymphoid tissues.
	Reduced circulating lymphocytes
	Reduced CNS infiltration of inflammatory cells
	Reduces memory B cells
	Increases number and CNS infiltration of regulatory B cells