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Isocitrate-αKG cycle modulates the NADP/NADPH balance. IDH1 is a cytosolic enzyme, IDH2 is mitochondrial enzyme. Both IDH1 and IDH2 catalyze the conversion between isocitrate and αKG, and the reverse reaction, i.e., the reductive carboxylation of αKG yielding to isocitrate. The forward reaction reduces NADP to NADPH, while the reverse reaction converts NADPH to NADP.
