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. 2023 Feb 1;24(3):2742. doi: 10.3390/ijms24032742

Figure 2.

Figure 2

Characterization of the humoral response elicited by OAg+ and OAg− S. flexneri GMMA in mice immunized intraperitoneally at day 0 and 28 with 10 µg of total GMMA proteins. (a) S. flexneri OAg-specific total IgG (EU/mL) after prime; (b) S. flexneri OAg-specific total IgG (EU/mL) after boost; (c) S. flexneri GMMA proteins-specific total IgG (EU/mL) after prime; (d) S. flexneri GMMA proteins-specific total IgG (EU/mL) after boost. (e) Bactericidal and (f) opsonophagocytic titers after boost expressed as IC50. Geometric mean (bar) is reported for all groups together with individual values (dots) and 95% confidence intervals (CI). Dotted lines represent titer of pre-immune sera in panel (a–d), titer of not bactericidal sera in panel (e) and titer of not opsonizing sera in panel (f). * p < 0.05; ** p < 0.01; *** p < 0.001; ns p > 0.05, Mann–Whitney test.