Figure 1.

Experimental approach and weight assessment. After standard housing until the age of 2 months, Tg4-42 mice were assigned to standard (SH) or enriched housing (EE) conditions and received either tap water or caffeine-supplemented water for a period of 4 months. At 6 months of age, mice underwent a behavioral analysis (BA) with ongoing treatment (a). Body weight was assessed during the behavioral analysis and no statistically significant differences were detected among the treatment groups (b). One-way ANOVA followed by Bonferroni’s multiple comparison.