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Mechanism of increasing apoptosis of cancer cells when miR-4728 does not inhibit NOXA. NOXA displaces BAK1 from MCL-1 as they have a similar conformation. The MCL-1/NOXA complex activates BCL-2, which activates the apoptosis of cancer cells. NOXA—NADPH oxidase activator, MCL-1—mantle cell lymphoma 1 protein, BCL-1—B cell lymphoma 1 protein, BCL-2—B cell lymphoma 2 protein, BAK1—BCL-2 homologous antagonist killer.
