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. 2023 Jan 19;24(3):1992. doi: 10.3390/ijms24031992

Figure 5.

Figure 5

DEPDC1 promoted OSCC progression via the WNT/β-catenin signaling pathway. (A,B), Overexpression of DEPDC1 enhanced the migration and invasion of SCC9 and SCC15, while XAV939, an inhibitor of the WNT/β-catenin signaling pathway, could weaken the migration (SCC9 p = 0.0039; p = 0.0081, SCC15 p = 0.0024; p = 0.0134) and invasion ability (SCC9 p = 0.0005; p = 0.0138, SCC15 p = 0.0005; p = 0.0011) after overexpression of DEPDC1. (C), Meanwhile, upregulation of DEPDC1 induced higher N-cad (SCC9 p = 0.0024; p = 0.0042, SCC15 p = 0.0002; p = 0.0012) and β-catenin expression (SCC9 p = 0.0021; p = 0.0114, SCC15 p = 0.0014; p = 0.0075) and lower E-cad expression (SCC9 p = 0.0047; p = 0.0131, SCC15 p = 0.0064; p = 0.0004), while the protein level could also be reversed by XAV939. N-cad: N-cadherin, E-cad: E-cadherin, Con: control, OE: overexpression of DEPDC1. Significant differences were considered at p < 0.05 *; p < 0.01 **; p < 0.001 ***.