Figure 1.

The development of the Collaborative Cross (CC) mouse model. This breeding approach was designed to randomize the genetic composition of each inbred line. A single breeding funnel results in a recombinant CC inbred line representing the genomes of the eight founders of CC mice. The eight founding tribes are arranged in different positions. Each CC line originates from an independently breeding funnel of eight CC founders so that at every recombination site in the CC population is uniquely generated.