Figure 2.

Workflow for the creation of system genetic databases from the CC population, which is incredibly heterogeneous and may have vastly different susceptibilities to class III malocclusion. Class II and III malocclusion in mice is checked. The analysis of numerous associations between malocclusion and class III traits uses cellular, molecular, and clinical trait data. The regulatory genomic areas are implicated in phenotypic variance in both in vitro and in vivo monitored traits when SNP genotype data from each CC lineage are combined. Combining data with later candidate gene association research in humans may help find susceptibility genes linked to the emergence of class III malocclusion in people.