Table 2.

Uni- and multivariate Cox analyses of prognostic factors in the TCGA cohort.

	Univariate Analysis		Multivariate Analysis
	HR (95% CI)	p-Value	HR (95% CI)	p-Value
Age
<70	Ref.		Ref.
≥70	1.610 (1.127, 2.298)	0.009	2.281 (1.493, 3.487)	<0.001
Gender
female	Ref.
male	1.020 (0.679, 1.533)	0.923
pT stage
pT1-2	Ref.		Ref.
pT3-4	1.700 (1.157, 2.499)	0.007	1.052 (0.654, 1.692)	0.552
pN stage
pN0-1	Ref.		Ref.
pN2-3	1.842 (1.275, 2.662)	0.001	1.433 (0.934, 2.197)	0.142
pM stage
pM0	Ref.
pM1	2.211 (0.899, 5.439)	0.084
pTNM stage
Stage II	Ref.		Ref.
Stage III-IV	2.193 (1.314, 3.660)	0.003	1.598 (0.826, 3.094)	0.138
Lymphovascular invasion
No	Ref.		Ref.
Yes	1.779 (1.249, 2.533)	0.001	1.410 (0.947, 2.100)	0.070
TSR
Stroma-low	Ref.		Ref.
Stroma-high	2.346 (1.537, 3.581)	<0.001	2.622 (1.712, 4.015)	<0.001

95% CI, 95% Confidence Interval.