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Metabolic pathways supported by NOX2 expression and NOX2-related ROS generation. HIF1α: Hypoxic Inducible Factor 1 α; PDK1: pyruvate dehydrogenase kinase 1; PDH: pyruvate dehydrogenase; HK2: Hexokinase II; PFKFB3: 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase.
