Table 3.
Differences in serum levels of HDL subclasses between HV and MS patients.
| Variable (mg/dL) | All (N = 130) |
HV (N = 65) |
MS (N = 65) |
p |
|---|---|---|---|---|
| HDL-C | 58.6 (51.3, 69.2) | 65.2 (57.7, 74.5) | 52.7 (47.9, 60.6) | <0.001 |
| HDL1-C | 17.2 (13.8, 22.5) | 18.4 (15.1, 26.8) | 15.7 (12.9, 20.1) | 0.001 |
| HDL2-C | 8.6 (7.5, 10.2) | 9.5 (8.3, 12.6) | 8.2 (7.3, 9.7) | 0.001 |
| HDL3-C | 11.2 (10.0, 13.2) | 12.2 (10.7, 13.6) | 10.4 (9.6, 11.9) | <0.001 |
| HDL4-C | 20.5 (17.2, 23.9) | 22.3 (18.2, 24.7) | 19.0 (16.0, 22.7) | 0.001 |
| HDL-TG | 10.5 (9.0, 13.3) | 9.9 (8.7, 11.8) | 11.4 (9.7, 13.6) | 0.006 |
| HDL1-TG | 3.3 (2.6, 4.4) | 3.0 (2.5, 4.2) | 3.6 (2.7, 4.6) | 0.326 |
| HDL2-TG | 1.8 (1.5, 2.3) | 1.6 (1.3, 2.1) | 2.0 (1.6, 2.5) | 0.001 |
| HDL3-TG | 2.3 (1.9, 2.8) | 2.1 (1.7, 2.5) | 2.7 (2.1, 3.1) | <0.001 |
| HDL4-TG | 3.6 (3.0, 4.3) | 3.4 (2.5, 3.9) | 3.7 (3.3, 4.7) | <0.001 |
| HDL-PL | 81.9 (72.1, 93.2) | 89.4 (79.2, 99.8) | 77.1 (67.5, 84.5) | <0.001 |
| HDL1-PL | 20.5 (16.8, 26.5) | 22.1 (18.6, 33.9) | 18.9 (14.8, 22.9) | 0.002 |
| HDL2-PL | 13.8 (11.7, 15.9) | 14.4 (12.6, 18.6) | 13.2 (10.9, 15.4) | 0.017 |
| HDL3-PL | 18.2 (15.9, 20.6) | 19.1 (17.4, 20.9) | 17.1 (15.2, 19.6) | 0.004 |
| HDL4-PL | 28.8 (25.4, 31.8) | 29.9 (26.4, 32.7) | 26.3 (23.1, 30.7) | 0.003 |
| HDL-apoA-I | 159.3 (144.5, 178.2) | 167.8 (155.7, 183.7) | 149.2 (138.1, 166.2) | <0.001 |
| HDL1-apoA-I | 26.3 (20.0, 34.7) | 27.5 (22.3, 45.4) | 24.9 (18.5, 30.1) | 0.007 |
| HDL2-apoA-I | 18.7 (16.3, 22.1) | 19.6 (17.2, 23.3) | 17.5 (15.2, 20.6) | 0.004 |
| HDL3-apoA-I | 30.2 (26.7, 33.3) | 30.8 (27.5, 33.5) | 28.8 (24.9, 32.5) | 0.040 |
| HDL4-apoA-I | 79.5 (70.8, 89.0) | 81.9 (72.7, 91.1) | 75.5 (68.3, 86.5) | 0.023 |
| HDL-apoA-II | 35.2 (32.2, 38.4) | 36.0 (33.6, 38.6) | 33.8 (31.5, 37.5) | 0.039 |
| HDL1-apoA-II | 2.4 (1.9, 3.5) | 2.5 (2.1, 4.1) | 2.1 (1.6, 3.0) | 0.006 |
| HDL2-apoA-II | 3.9 (3.2, 4.6) | 4.0 (3.5, 4.6) | 3.7 (3.0, 4.5) | 0.111 |
| HDL3-apoA-II | 7.3 (6.5, 8.2) | 7.3 (6.9, 8.1) | 7.1 (6.3, 8.4) | 0.739 |
| HDL4-apoA-II | 19.8 (17.5, 22.6) | 20.9 (18.4, 23.2) | 19.2 (17.0, 21.9) | 0.060 |
Data are presented as median (q1, q3). Differences between HV and MS patients were tested using the Mann–Whitney U test. p-values < 0.05 are considered statistically significant and are depicted in bold. ApoA-I, apolipoprotein A-I; apoA-II, apolipoprotein A-II; C, cholesterol; dL, deciliter; HV, healthy volunteer; HDL, high-density lipoprotein; mg, miligram; MS, metabolic syndrome patient; N, number; PL, phospholipid; TG, triglyceride.