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Effect of the test compounds on NO production. Raw 264.7 macrophage cultures were treated with the selected concentrations of the test compounds or the vehicle (0.1% DMSO) for 1 h followed by the addition of LPS and further incubation for 18 h. Each column represents the mean ± SEM of three independent experiments. * p < 0.05, ** p < 0.01, *** p < 0.001 and **** p < 0.0001 relative to LPS-treated cells (V + LPS). # p < 0.05 and ## p < 0.01 among all the concentrations tested.
