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. 2023 Jan 25;24(3):2340. doi: 10.3390/ijms24032340

Figure 2.

Figure 2

Biological processes involved in sevoflurane protection against HIRI. Akt = protein kinase B; Bax = Bcl-2-associated X protein; Bcl-2 = B-cell lymphoma 2; eIF2α = Eukaryotic Initiation Factor 2 α; Grp-78 = glucose-regulated protein 78; GSK3β = glycogen synthase kinase-3 beta; HGF = hepatocyte growth factor; HIRI = hepatic ischemia-reperfusion injury; HMGB1 = high mobility group box 1; HO-1 = heme oxygenase 1; ICAM-1 = Intercellular Adhesion Molecule 1; IκBα = NF-κB inhibitor alpha; JAK = janus kinase; JNK = c-Jun N-terminal kinase; MET = Met tyrosine kinase receptor; miRNA = microRNA; mPTP = mitochondrial permeability transition pore; mTOR = mechanistic target of rapamycin; NF-κB = Nuclear factor kappa-light-chain-enhancer of activated B cells; PERK = protein kinase R-like endoplasmic reticulum kinase; PI3K = Phosphoinositide 3-kinase; p-p65 = phosphorylated p65; STAT3 = signal transducer and activator of transcription protein 3; TLR4 = toll-like receptor 4; and TRAF-6 = TNF receptor-associated factor 6.