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. 2023 Jan 27;24(3):2469. doi: 10.3390/ijms24032469

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Quantitative PCR (qPCR) showing mRNA expression levels of ADAM10 in muscle biopsies of control subjects (CTRL) and DM and IMNM patients. Gene expression was normalized to the mean of housekeeping genes (GAPDH and B2M) and plotted as fold increase from CTRL (a). D’Agostino and Pearson normality test and Kruskal–Wallis test with two-group comparison by Dunn’s multiple comparisons test were performed. Data are presented as box-and-whisker plot with median and interquartile ranges from max to min with all data points shown; significant results were indicated by p value. FNDC5 mRNA levels negatively correlated with ADAM10 mRNA levels (b.) Irisin serum levels are positively associated with ADAM10 mRNA levels (c). For linear regression, r and p values are as indicated.