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. 2023 Jan 21;24(3):2161. doi: 10.3390/ijms24032161

Figure 10.

Figure 10

HPLC measurements after seeded aggregation of tau with soluble tau oligomers. Tau monomer with a concentration of 100 nM was incubated with 100 nM soluble tau oligomers and variable sub-stoichiometric concentrations of TF2D-5, TF2D-5a, and CP1. (A) CP1 was added at a concentration of 50 nM to the sample. No deviation from the reference sample was observed. (B) TF2D-5 was added at a concentration of 50 nM to the sample. We observed an increase in the retained tau monomer peak (8–8.5 min) with increasing concentrations of TF2D-5. (C) TF2D-5a was added at a concentration of 50 nM. We observed a stronger increase in the retained monomer peak than with TF2D-5. Additionally, we observed that the oligomer peak decreased in height.