Figure 1.

Resveratrol and piceatannol hold vigorous cytokine-inhibiting roles in L. acidophilus NCFM-stimulated bmDCs, and methylation of resveratrol weakens the inhibitory capabilities. Murine bmDCs were stimulated with L. acidophilus NCFM at multiplicity of infection (MOI) at rates of 0.3, 1, and 3 (A) and incubated for 20 h. To assess the effect of monomers on the cytokine response, bmDCs were incubated with increasing concentrations (0–40 µM) of resveratrol (B), piceatannol (C), pterostilbene (D), pinostilbene (E), and trimethoxy-resveratrol (F) for 30 min before L. acidophilus NCFM (MOI 1) was added to the samples. Cytokine levels in the supernatant for stilbenoid-treated samples (B–F) are shown as percentages of samples with no stilbenoid treatment (0 µM). The depicted data are representative of at least three experiments. * p ≤ 0.05, ** p ≤ 0.01, *** p ≤ 0.001, **** p ≤ 0.0001.