Table 1.
Monomeric C-reactive protein assays.
| Assay Type | Anti-mCRP Antibody | Blood-Specimen Type |
Reported mCRP Levels | Correlation (mCRP/ hsCRP) |
Reference |
|---|---|---|---|---|---|
| ELISA | Unspecified mAb | Heparinized plasma | 20.96 ± 1.64 μg/L in acute myocardial infarction 0.0 μg/L in angina pectoris, unstable angina, and non-CAD patients |
n/a | Wang et al., 2015 [109] |
| ELISA | CRP-8 | Plasma (unspecified anticoagulant) |
59.8 (44.5; 79.1) μg/L in urticaria 35.4 (17.0; 48.6) μg/L in psoriasis 30.0 (4.77; 36.3) in eczema 15.2 (5.05; 27.1) μg/L in healthy participants |
n/a | Zhang et al., 2018 [110] |
| ELISA | CRP-8 | Serum purified by chromatography |
1.03 ± 0.11 mg/L in patients with hsCRP > 100 mg/L | None | Williams et al., 2020 [111] |
| ELISA | Unspecified mAb | EDTA plasma |
244.1 (226.1; 331.7) mg/L in AAV 170.0 (135.7; 199.3) mg/L in control participants |
Negative | Wu et al., 2020 [112] |
| ELISA | Aptamer | Serum | 0.66 (0.38; 1.03) mg/L in COPD 0.0 (0.0; 0.29) mg/L in non-COPD patients |
None | Munuswamy et al., 2021 [113] |
| ELISA | CRP-8 | Plasma (unspecified anticoagulant) |
12.5 (7.8; 24.8) μg/L in osteoarthritis 5.0 (3.5; 9.8) μg/L in healthy participants |
Positive | Liang et al., 2022 [114] |
| CBA | CRP-8 | Citrated plasma |
5.2 (3.3; 7.1) μg/L in patients with subclinical carotid atherosclerosis |
None | Melnikov et al., 2022 [115] |
| ELISA | 8C10 | Serum | 3.7 (1.3; 7.4) μg/L in systemic lupus erythematosus 11 (5.8; 22) μg/L in AAV patients |
None | Karlsson et al., 2022 [116] |
| ELISA | 12C | EDTA plasma |
477 (100; 2570) μg/L in adult-onset Still’s disease 186 (0.035; 626) μg/L in polymyalgia rheumatica 77 (0.035; 501) μg/L in rheumatoid arthritis 228 (0.035; 1086) μg/L in acute infections 1.2(0.035; 10) μg/L in healthy participants |
None | Fujita et al., 2022 [117] |
ELISA, enzyme-linked immunosorbent assay; CBA, cytometric bead array; mAb, monoclonal antibody; mCRP, monomeric C-reactive protein; hsCRP, pentameric C-reactive protein measured using high-sensitivity assay; EDTA, ethylenediaminetetraacetic acid; CAD, coronary artery disease; AAV, anti-neutrophil cytoplasmic antibody-associated vasculitis; COPD, chronic obstructive pulmonary disease; n/a, not assessed.