Table 5.
Univariate and multivariate Cox regression analysis of risk factors’ influences on the mortality of ccRCC patients.
| Univariate | Multivariate | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Variable | HR | 95% CI | p-Value | HR | 95% CI | p-Value | |||
| Age at diagnosis | 1.03 | 1.01 | 1.05 | 0.002 | 1.03 | 1.01 | 1.06 | 0.007 | |
| Stage of disease (ref. I) |
II | 0.29 | 0.14 | 0.63 | 0.001 | - | - | - | - |
| III | 3.68 | 2.17 | 6.25 | 0.502 | - | - | - | - | |
| IV | 34.31 | 14.38 | 81.88 | <0.001 | - | - | - | - | |
| Metastasis (ref. no) | Present | 4.80 | 3.23 | 7.13 | <0.001 | 3.64 | 2.22 | 5.94 | <0.001 |
| Necrosis (ref. no) | Present | 2.61 | 1.74 | 3.89 | <0.001 | 1.63 | 1.01 | 2.63 | 0.048 |
| Tumor size (ref. ≤ 70) | >70 mm | 2.48 | 1.69 | 3.64 | <0.001 | 1.73 | 1.06 | 2.82 | 0.027 |
| Sex (ref. female) | Male | 1.51 | 1.02 | 2.21 | 0.038 | 1.79 | 1.08 | 2.97 | 0.023 |
| rs1036199 (ref. AA) | AC + CC | 1.54 | 1.08 | 2.19 | 0.017 | 1.96 | 1.25 | 3.07 | 0.003 |
| rs10057302 (ref. CC) | AC + AA | 1.15 | 0.47 | 2.83 | 0.753 | - | - | - | - |
| rs3751093 (ref. GG) | AG + AA | 0.98 | 0.69 | 1.39 | 0.908 | - | - | - | - |
| rs361497 (ref. GG) | AG + AA | 0.89 | 0.62 | 1.27 | 0.511 | - | - | - | - |
| rs4239242 (ref. TT) | CT + CC | 0.91 | 0.64 | 1.30 | 0.608 | - | - | - | - |
| rs4794976 (ref. TT) | GT + GG | 1.02 | 0.72 | 1.45 | 0.918 | - | - | - | - |