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. 2023 Jan 23;24(3):2264. doi: 10.3390/ijms24032264

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Diagram representing all SARS-CoV-2 Omicron sublineages designated by PANGOLIN as of 26 December 2022 for which at least one of the Spike RBD immune escaping mutations (R346X, K444X, L452X, N460X, F486X, or R493Q) represents a branching event. Mythological names introduced by T Ryan Gregory and used colloquially are also reported. Convergence towards combos of this mutations is noted, with different background colors representing different combinations. Resistance of each combination to clinically authorized anti-Spike mAbs is reported in the squared box. For visualization purposes, the upper panel shows BA.1 and BA.2 evolution, while the lower panel shows BA.4/5 evolution.