Figure 5.

Expression of five of the phosphorylated proteins of the MAPK signaling pathway in HaCaT cells following 24 h treatment with LPS (5.0 µg/mL) in the presence of pCBs (THCV (9.3 µM) and CBGA (13.0 µM)) and selected eCB system antagonists and inhibitors (CPZ (5.0 μM), JZL184 (10.0 μM), LEI-106 (10.0 μM), URB597 (1.0 μM) and ARN19874 (33.7 μM)). Histograms for (A) AKT, (B) GSK3β, (C) mTor, (D) MEK1 and (E) MKK6. Data are presented as means ± SEM of three independent experiments (n = 3). Statistical analysis was performed using a one-way ANOVA test followed by a Bonferroni post hoc test. (* p < 0.05 vs. CTRL; # p < 0.05, ## p < 0.01, ### p < 0.001 vs. LPS).