Table 2.

Summary of the most significant effects of MAPK protein expression in response to eCB system elements in presence of antagonists and inhibitors after HaCaT cells were treated for 24 h with LPS and with THCV and CBGA. Legend: ↑ significant increase; ↓ significant decrease; + p < 0.05; ++ p < 0.01; +++ p < 0.001 vs. LPS, THCV and CBGA.

	THCV Effects				CBGA Effects
MAPKs	THCV	THCV + TRPV1 Antagonist (CPZ)	THCV + MAGL Inhibitor (JZL184)	THCV + DAGLs Inhibitor (LEI-106)	CBGA	CBGA + TRPV1 Antagonist (CPZ)	CBGA + FAAH Inhibitor (URB597)	CBGA + NAPE-PLD Inhibitor (ARN19874)
AKT								↑ ++ vs. LPS
GSK3 β						↑ + vs. LPS	↑ + vs. LPS
mTor		↑ + vs. LPS	↑ + vs. LPS				↑ +++ vs. LPS
MEK1	↓ ++ vs. LPS		↓ ++ vs. LPS	↓ + vs. LPS	↓ ++ vs. LPS	↓ +++ vs. LPS
MKK6	↓ + vs. LPS	↓ + vs. LPS	↓ ++ vs. LPS	↓ ++ vs. LPS	↓ ++ vs. LPS	↓ +++ vs. LPS	↓ + vs. LPS	↓ + vs. LPS
CREB	↓ ++ vs. LPS		↑ ++ vs. THCV	↓ ++ vs. LPS	↓ ++ vs. LPS	↓ ++ vs. LPS	↑ +++ vs. CBGA
RSK1							↑ + vs. CBGA
RSK2							↑ +++ vs. CBGA