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Dendritic cell role in cancer immunosuppression. (A). Under the influence of AFP, dendritic cells (DCs) stimulate the formation of Tregs, and block the activity of CD8+ and NK lymphocytes, which promotes the formation of an immunosuppressive environment and tumor development; (B). In the conditions of a healthy organism, DCs stimulate the activity of CD4+, Cd8+ and NK lymphocytes, which blocks the development of cancer.
