ADT	androgen deprivation therapy
AGC	protein kinase A, G and C families
AKT	protein kinase B
AR-FL	androgen receptor full length
AR-V	androgen receptor splice variants
AR	androgen receptor
ARA	androgen receptor antagonist
ARE	androgen response element
ARSI	androgen receptor signaling inhibitor
ATP	adenosine triphosphate
BAD	Bcl-2-associated death promoter
BAT	bipolar androgen therapy
CRPC	castration-resistant prostate cancer
CSPC	castration-sensitive prostate cancer
CTC	circulating tumor cells
CTD	hydrophobic regulatory motif domain
CTLA4	cytotoxic T-lymphocyte-associated protein 4
CYP17A1	cytochrome P450 17α-hydroxylase/17,20-lyase
DBD	DNA-binding domain
DHEA	dehydroepiandrosterone
DHT	5α-dihydrotestosterone
DNA	deoxyribonucleic acid
FDA	Food and Drug Administration
FISH	fluorescence in situ hybridization
FKBP5	FK506 binding protein 5
FOXO	forkhead box transcription factors
FSH	follicle-stimulating hormone
GnRH	gonadotropin-releasing hormone
GPCR	G-protein-coupled receptor
GSK 3	glycogen synthase kinase 3
HER	human epidermal growth factor receptor
HPG	hypothalamus–pituitary–gonadal axis
HSP	heat-shock protein
iNOS	inducible nitric oxide synthase
KO	knockout
LBD	ligand-binding domain
LH	luteinizing hormone
LHRH	luteinizing hormone-releasing hormone
LNCaP	androgen-sensitive human prostate adenocarcinoma cells
mCRPC	metastatic castration-resistant prostate cancer
mCSPC	metastatic castration-sensitive prostate cancer
mRNA	messenger ribonucleic acid
mTOR	mammalian target of rapamycin
mTORC1/2	mTOR complex ½
nmCRPC	non metastatic castration-resistant prostate cancer
NOS	nitric oxide synthase
NTD	amino-terminal transcriptional domain
OS	overall survival
p70S6K	p70S6 kinase
PARP	poly ADP-ribose polymerase
PCa	prostate cancer
PCR	polymerase chain reaction
PD-L1	programmed death-ligand 1
PD1	programmed cell death protein 1
PDK1	phosphoinositide-dependent kinase 1
PFS	progression-free survival
PH	pleckstrin homology domain
PHLPP	PH domain of leucine repeat sequence-rich phosphatase
PI(3,4)P2	phosphatidylinositol-3,4-biphosphate
PI(4,5)P2	phosphatidylinositol-4,5-biphosphate
PI3K	phosphatidylinositol-3-kinase
PIP3	phosphatidylinositol-3,4,5-triphosphate
PKA	protein kinase A
PSA	prostate-specific antigen
PTEN	phosphatase and tensin homolog
RANKL	receptor activator of nuclear factor kappa-B ligand
RICTOR	rapamycin-insensitive companion of mTOR
RNA	ribonucleic acid
RP	radical prostatectomy
rPFS	radiographic progression-free survival
RT-PCR	real time polymerase chain reaction
RT	radiotherapy
RTK	receptor tyrosine kinase
SHBG	sex hormone-binding globulin
TSC 2	tuberosis sclerosis complex 2
Vps34	vacuolar protein signal 34