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The main putative molecular mechanisms involved in the anti-obesity effects of metformin mediated by brown adipose tissue function. AMPK: AMP-activated protein kinase, FGF21: fibroblast growth factor 21, Nrf1: nuclear respiratory factor 1: PGC-1α, peroxisome-proliferator-activated receptor gamma coactivator 1-alpha, UCP1: uncoupling protein 1, mg: milligram, kg; kilogram, wks: weeks.
