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. 2023 Jan 30;24(3):2586. doi: 10.3390/ijms24032586

Figure 1.

Figure 1

CSF hypersecretion and hydrocephalus occurs in SHRs at seven weeks of age. (A) Left, schematic of the method used for in vivo quantification of CSF secretion in rats. Right, direct measurement of CSF secretion in a live rat. (B) Quantification of the rate of CSF secretion at weeks 5 (n = 3), 6 (n = 3), and 7 (n = 6). * p < 0.05 versus WKY rats at week 7. (C) Representative photomicrographs of coronal sections of rat brains (at −0.6 mm from the bregma) depicting ventricular volume at week 7 in SHRs compared with age-matched WKY rats. Scale bar, 2 mm. (D) Quantification of lateral ventricle volume in SHRs (n = 6) and WKY rats (n = 6) at weeks 7. * p < 0.05 versus WKY rats at week 7. (E,F) SHRs had significantly higher systolic blood pressure and mean arterial pressure than WKY rats at weeks 5 (n = 3), 6 (n = 3), and 7 (n = 6). * p < 0.05 versus WKY group. Values are means ± SD.