Table 1.
Mechanism of action and cure rate of medical treatment options for PPI.
| Options | Mechanism of Action | Cure Rate |
|---|---|---|
| Duloxetine | Stimulation of pudendal nerve, leading to increased tension of the urethral sphincter and relaxation of detrusor muscle | Dry rate: 25–89% [116] |
| Antimuscarinic | Antagonizing effect of muscarinic receptor subtypes in the bladder such as bladder contractions | Improvement in urge incontinence: up to 52% [129] |
| Solifenacin | ||
| Tolterodine | Decrease in early urge incontinence after RPRP: up to 53% [128] | |
|
Beta-3
Agonists Mirabegron |
Stimulation of beta-3 adrenoceptors in smooth muscle cells of detrusor induces detrusor relaxation | Reduced daily micturition: 37% [132] |