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The schematic mechanism of cGAS-STING pathway-mediated apoptosis. ➀ cGAS-STING pathway can induce apoptosis through ER stress, ➁ through NLRP3 pathway, ➂ through NF-κB pathway, ➃ through the interaction of IRF3 and Bax, ➄ and through IFN-I production.
