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. 2023 Feb 1;24(3):2797. doi: 10.3390/ijms24032797

Figure 1.

Figure 1

The effect of inhibitors of ATM, ATR, and DNA-PKcs on HIV-1 post-integrational repair. (A–C) Analysis of the relative luciferase expression in 293T cells transduced by HIV_wt in presence of increasing concentrations of Ku-55933 (iATM), AZ20 (iATR), and Nu7441 (iDNA-PK). (D) The effect of azidothymidine (AZT), raltegravir (Ral), iATM, and iDNA-PK on luciferase expression in 293T cells transduced by HIV_wt. (E,F) The level of the total viral DNA (E) and integrated viral DNA (F) in 293T cells transduced by HIV_wt in presence of AZT, Ral, iATM, and iDNA-PK. (G) Efficiency of post-integrational DNA repair in 293T cells transduced by HIV_wt in presence of iATM or iDNA-PK. Mean values ± SD of three (D–G) or four (A–C) independent experiments are presented. Significance was determined by one-way ANOVA with Dunnett’s correction for multiple comparisons, ns—not significant, * = adj. p-value < 0.05, ** = adj. p-value < 0.01, **** = adj. p-value < 0.0001.