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. 2023 Feb 1;24(3):2797. doi: 10.3390/ijms24032797

Figure 2.

Figure 2

The effect of ATM and DNA-PKcs inhibitors on luciferase activity in 293T cells transduced by HIV_wt and HIV_mut. (A) HIV_mut transduced 293T cells five times worse than HIV_wt. Significance was determined by two-tailed Student’s t-test, *** = p < 0.001. (B,C) Analysis of the relative luciferase expression in 293T cells transduced by HIV_wt or HIV_mut in presence of increasing concentrations of Nu7441 (iDNA-PK) or Ku-55933 (iATM). Data for HIV_wt or HIV_mut were normalized to 0 μM points for each vector independently. Mean values ± SD of three (A) or four (B,C) independent experiments are presented. Significance was determined by two-way ANOVA with Sidak’s correction for multiple comparisons, * = adj. p-value < 0.05, ** = adj. p-value < 0.01, *** = adj. p-value < 0.001, **** = adj. p-value < 0.0001.