Table 2.
Impact of underweight on SCD in DM patients.
| N | SCD | Follow-Up Duration (Person-Years) |
Incidence | Hazard Ratio with 95% Confidence Interval | |||
|---|---|---|---|---|---|---|---|
| Non-Adjusted | Model 1 | Model 2 | |||||
| Underweight | |||||||
| No (BMI ≥ 18.5) | 2,560,979 | 25,259 | 17,604,724 | 1.43 | 1 (reference) | 1 (reference) | 1 (reference) |
| Yes (BMI < 18.5) | 41,598 | 1082 | 247,073 | 4.38 | 3.11 (2.93–3.31) | 2.56 (2.41–2.72) | 2.40 (2.26–2.56) |
| BMI value | |||||||
| BMI < 18.5 | 41,598 | 1082 | 247,073 | 4.38 | 2.29 (2.15–2.44) | 2.01 (1.94–2.20) | 2.01 (1.88–2.14) |
| 18.5 ≤ BMI < 23 | 648,206 | 8491 | 4,355,959 | 1.95 | 1 (reference) | 1 (reference) | 1 (reference) |
| 23 ≤ BMI < 25 | 645,444 | 6401 | 4,457,801 | 1.44 | 0.73 (0.71–0.76) | 0.75 (0.73–0.78) | 0.77 (0.75–0.80) |
| 25 ≤ BMI < 30 | 1,066,439 | 8844 | 7,408,578 | 1.19 | 0.61 (0.59–0.63) | 0.69 (0.67–0.71) | 0.71 (0.69–0.74) |
| BMI ≥ 30 | 200,890 | 1523 | 1,382,385 | 1.10 | 0.57 (0.54–0.60) | 0.89 (0.84–0.94) | 0.89 (0.84–0.94) |
Incidence is per 1000 person-years of follow-up. BMI: body-mass index; DM: diabetes mellitus; SCD: sudden cardiac death. Model 1: adjusted for age and sex. Model 2: adjusted for age, sex, income level, smoking history, alcohol consumption, regular physical activity, hypertension, dyslipidemia, fasting glucose, duration of DM, use of insulin, and number of oral antidiabetic medications.